Glass or Plastic? An HPLC Vial Compatibility Study for Dilute Benzalkonium Chloride (BAK) Solutions

Authors

Avery Stadler
Brett D. Seaman
Priyanka Bhatt, St. John Fisher UniversityFollow
Fang Zhao, St. John Fisher UniversityFollow

Document Type

Article

Publication Date

11-4-2025

Abstract

Key Takeaways

• BAK's amphiphilic nature causes adsorption on surfaces, complicating HPLC analysis, especially in glass vials due to ionic interactions with silanol groups.
• Plastic polypropylene vials showed minimal BAK adsorption loss, outperforming glass vials, including premium and silanized types.
• Early vial compatibility assessments are crucial in HPLC method development for dilute BAK solutions to mitigate adsorption issues.
• The study highlights the complexity of predicting BAK adsorption behavior due to multiple influencing factors, necessitating experimental testing for vial compatibility.

Publication Information

Stadler, Avery; Seaman, Brett D.; Bhatt, Priyanka; and Zhao, Fang (2025). "Glass or Plastic? An HPLC Vial Compatibility Study for Dilute Benzalkonium Chloride (BAK) Solutions." LCGC International .

Please note that the Publication Information provides general citation information and may not be appropriate for your discipline. To receive help in creating a citation based on your discipline, please visit https://libguides.sjf.edu/citations.