Sustainable Green Biomaterials in Biomimetic Drug Delivery
Document Type
Article
Publication Date
2-2024
Abstract
While the use of tablets, capsules, suspensions, emulsions, and gels remains the convention for parenteral or injectable treatments, the recent exploration of micro and nano-colloidal systems (like albumin microspheres, liposomes, exosomes, DNA origamis, and others) has provided new opportunities to modulate the drug delivery profile or improve its pharmacologic response. One of the first use of biomimetic materials was the exploration of liposomes that mimic the phospholipid bilayer of membranes as potential delivery systems. The use of particle structures (nano, micro, or bubbles) given by intravenous route has evolved rapidly from being used as drug delivery vectors to potential theranostic agents or even having the potential for developing biomimetic drug delivery system. For making these innovative products, selecting appropriate biomaterials is the key to success. Also, the scientific purpose and economic ease play a critical role in biomaterial selection. Researchers often use conventional semi-synthetic biomaterials (cellulose derivatives, polylactic acid polymers, or polyethylene glycol (peg) derivatives) to make innovative advanced drug delivery designs. A "nano-shop" can be envisioned with various innovative nano drug delivery systems made from primarily synthetic and semi-synthetic materials that were built on the idea of exploring biomimetic systems (e.g. (i) liposomes made from a phospholipid to mimic the bilayer of the cell, (ii) polymeric micelle from cellulose). Hence, it is essential to re-route the attention toward green biomaterials (proteins, polysaccharides, oligonucleotides, and lipids) that can offer sustainability to the science of advanced formulation development by keeping the biomimetic effect at the center of pharmaceutical innovations. Specifically, this article summarizes possibility of using albumin, deoxynucleic acid (DNA), and extracellular matrix (ECM) components (hyaluronic acid, and collagen) as sustainable green materials for developing biomimetic therapies like nanoparticles, microbubbles, gels, films 3D printable scaffolds and others.
Publication Information
Quinn, Morgan; Georgeadis, Samantha; Said, Marwa; Narh, Sheila; Bajaj, Aditya; and Rochani, Ankit (2024). "Sustainable Green Biomaterials in Biomimetic Drug Delivery." AAPS Newsmagazine .
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