Document Type
Article
Publication Date
7-14-2018
Abstract
The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes
DOI
https://doi.org/10.3390/molecules23071719
Publication Information
Gupta, Deepak; Bhatia, Deepak; Dave, Vivek S.; Sutariya, Vijaykumar B.; and Gupta, Sheeba Varghese (2018). "Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations." Molecules 23.7, 1719-.
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Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
© 2018 by the authors. This open access article is also available on the publisher's website: https://doi.org/10.3390/molecules23071719.