Pharmacist-Led Management of Treatment-Resistant Hypertension

Document Type

Poster Presentation

Publication Date

4-17-2026

Keywords

fsc2026

Abstract

Background: Treatment-resistant hypertension (TRH) is defined as uncontrolled blood pressure (BP) on three or more medications or controlled BP on four or more medications. Patients with TRH are at higher risk of poor health outcomes compared to patients with non-resistant hypertension; this risk increases in patients with comorbidities such as diabetes, chronic kidney disease (CKD), or cardiovascular disease. Ambulatory care pharmacists are well positioned to address high-risk TRH. This study seeks to evaluate the impact of a pharmacist-led intervention on blood pressure control in high-risk TRH patients.

Objectives: The primary objective is to evaluate the impact of a pharmacist-led intervention utilizing home blood pressure cuffs on blood pressure control in high-risk TRH patients. Secondary objectives include assessing the proportion of patients achieving target BP (< 130/80 mmHg) and quantifying medication changes.

Methods: This study was approved by the Institutional Review Board, and informed consent was obtained for all subjects. This is a prospective, single-arm quality improvement project conducted across three Jordan Health sites. Eligible participants are greater than 18 years old with a diagnosis of uncontrolled hypertension on at least three antihypertensive medications and one or more high-risk comorbidities (diabetes, chronic kidney disease stage 3-5, or cardiovascular disease). Patients who have consented will be voluntarily enrolled for three appointments with a clinical pharmacist and given a home blood pressure cuff. The three appointments will include medication reconciliation, education on home blood pressure monitoring, lifestyle counseling, and therapeutic optimization in collaboration with primary care providers. Ambulatory blood pressure monitoring will be selectively employed in cases of diagnostic uncertainty or poor treatment response. Simple descriptive and comparative statistics will be used to describe outcomes.

Comments

Poster presented at the 2026 Fisher Showcase, St. John Fisher University, April 17, 2026.

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