Hyaluronic Acid: A Sustainable Green Polysaccharide for Formulation and Therapeutic Applications

Authors

• Tala Alzien, St. John Fisher University
• Annelise McLean, St. John Fisher University
• Valerie Malachin, St. John Fisher University
• Sara Woytowicz, St. John Fisher University
• Valentine Orock, St. John Fisher University
• Jack Pietro, St. John Fisher University
• Abhishek Tiwari, St. John Fisher University
• Todd D. Camenisch, St. John Fisher UniversityFollow
• Vivek S. Dave, St. John Fisher UniversityFollow
• Ankit Rochani, St. John Fisher UniversityFollow

Document Type

Poster Presentation

Publication Date

4-17-2026

Keywords

fsc2026

Abstract

Hyaluronic acid (HA) is a sustainable, biomimetic biopolymer widely used in pharmaceutical and biomedical formulations. HA exists across a broad molecular weight range, where high‑molecular‑weight (HMW) HA is generally associated with biocompatibility and tissue homeostasis, while low‑molecular‑weight (LMW) HA fragments may induce pro‑inflammatory and immunomodulatory effects, raising important formulation and safety considerations. Despite extensive use of HA‑based products, awareness of molecular weight–dependent biological effects remains limited. This review highlights diverse HA‑based dosage forms; including hydrogels, nanofibers, particles, vesicular systems, films, microneedles, and injectables, and emphasizes the need for informed selection of HA type to support safe, effective, and personalized drug delivery applications.

Comments

Poster presented at the 2026 Fisher Showcase, St. John Fisher University, April 17, 2026.

Publication Information

Alzien, Tala; McLean, Annelise; Malachin, Valerie; Woytowicz, Sara; Orock, Valentine; Pietro, Jack; Tiwari, Abhishek; Camenisch, Todd D.; Dave, Vivek S.; and Rochani, Ankit, "Hyaluronic Acid: A Sustainable Green Polysaccharide for Formulation and Therapeutic Applications" (2026). Fisher Showcase 2026. Paper 43.
https://fisherpub.sjf.edu/fsc2026/43

Please note that the Publication Information provides general citation information and may not be appropriate for your discipline. To receive help in creating a citation based on your discipline, please visit https://libguides.sjf.edu/citations.