Lisinopril-Induced Angioedema Triggered by Tattoo Cellulitis and Acute Kidney Injury: A Case Report

Authors

• Mechal Zedan, Rochester Regional Health
• Stephen Howard, Rochester Regional Health
• Preston Foryt, St. John Fisher University
• Tarilate Aroriode, Rochester Regional Health

Document Type

Poster Presentation

Publication Date

4-17-2026

Keywords

fsc2026

Abstract

Angiotensin-converting enzyme inhibitor-induced angioedema is a rare, potentially life-threatening disorder. This mostly manifests with swelling of the lips, tongue, and face with no known reports of angiotensin-converting enzyme inhibitor-induced angioedema from soft-tissue infections. We present herein a case of a 47-year-old male with a history of chronic kidney disease stage III who developed acute upper lip angioedema and severe acute kidney injury while on lisinopril/hydrochlorothiazide, following tattoo-related cellulitis. We propose that inflammatory activation from cellulitis amplified kallikrein-kinin system activity and bradykinin generation, precipitating angioedema in the setting of angiotensin-converting enzyme inhibition and transient renal dysfunction. This case highlights a rare but important intersection between infection-driven inflammation and angiotensin-converting enzyme inhibitor-induced angioedema.

Comments

Poster presented at the 2026 Fisher Showcase, St. John Fisher University, April 17, 2026.

Publication Information

Zedan, Mechal; Howard, Stephen; Foryt, Preston; and Aroriode, Tarilate, "Lisinopril-Induced Angioedema Triggered by Tattoo Cellulitis and Acute Kidney Injury: A Case Report" (2026). Fisher Showcase 2026. Paper 225.
https://fisherpub.sjf.edu/fsc2026/225

Please note that the Publication Information provides general citation information and may not be appropriate for your discipline. To receive help in creating a citation based on your discipline, please visit https://libguides.sjf.edu/citations.