Generation of EPO independent cells lines through CRISPR modification of EPOR and JAK2

Authors

• Reilly Morrow, St. John Fisher University
• Zachary MurphyFollow

Document Type

Poster Presentation

Publication Date

4-17-2026

Keywords

fsc2026

Abstract

Erythropoietin Receptor (EPOR) is an important receptor on cultured human erythroblasts (red blood cell precursors) that must be activated by the use of erythropoietin (EPO). EPO is prohibitively expensive to an undergraduate laboratory. In this project we will synthesize and test various sgRNAs to determine which has the highest efficiency of DNA manipulations of JAK2 for continued research.

Comments

Poster presented at the 2026 Fisher Showcase, St. John Fisher University, April 17, 2026.

Publication Information

Morrow, Reilly and Murphy, Zachary, "Generation of EPO independent cells lines through CRISPR modification of EPOR and JAK2" (2026). Fisher Showcase 2026. Paper 145.
https://fisherpub.sjf.edu/fsc2026/145

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