Comparative Analysis of Malate Dehydrogenase in Diverse Organisms

Authors

• Robert Leach, St. John Fisher University
• Morgan Sweetland, St. John Fisher University

Document Type

Poster Presentation

Publication Date

4-17-2026

Keywords

fsc2026

Abstract

Malate dehydrogenase (MDH) is an essential enzyme for metabolism, playing a crucial role within the Citric Acid Cycle. Occurring in the last step of the Citric Acid Cycle, MDH catalyzes the reaction of malate to oxaloacetate through its interaction with the cofactor NAD+/NADH. This presentation delivers an overview of both kinetic and procedural results of different MDH isoforms. Both plant (watermelon) and human variants were used to perform these reactions. This project also proposes future directions and mutants that could be made to further expand the knowledge of MDH.

Comments

Poster presented at the 2026 Fisher Showcase, St. John Fisher University, April 17, 2026.

Publication Information

Leach, Robert and Sweetland, Morgan, "Comparative Analysis of Malate Dehydrogenase in Diverse Organisms" (2026). Fisher Showcase 2026. Paper 128.
https://fisherpub.sjf.edu/fsc2026/128

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