Document Type
Article
Publication Date
6-1-2013
Department
Pharmacy
Abstract
Background
Intravenous or intracoronary adenosine is used in the cardiac catherization lab to achieve maximal coronary blood flow and determine fractional flow reserve.
Objective
To determine the stability of adenosine 10 and 50 µg/mL in either 0.9% sodium chloride injection or 5% dextrose injection in polyolefin infusion bags stored at 2 temperatures, refrigeration (2°C-8°C) or controlled room temperature (20°C-25°C).
Methods
Adenosine 10 µg/mL and 50 µg/mL solutions were prepared in 50 mL polyolefin infusion bags containing 0.9% sodium chloride injection or 5% dextrose injection and stored at controlled room temperature or under refrigeration. Each combination of concentration, diluent, and storage was prepared in triplicate. Samples were assayed using stability-indicating, reversed-phase high-performance liquid chromatography immediately at time 0 and at 24 hours, 48 hours, 7 days, and 14 days. Stability was defined as retaining 90% to 110% of the initial adenosine concentration. The samples were also visually inspected against a light background for clarity, color, and the presence of particulate matter.
Results
After 14 days, all samples retained 99% to 101% of the initial adenosine concentration. No considerable change in pH or visual appearance was noted. The stability data indicated no significant loss of drug due to chemical degradation or physical interactions during storage.
Conclusion
Adenosine solutions of 10 and 50 µg/mL were stable for at least 14 days in 50 mL polyolefin infusion bags of 0.9% sodium chloride injection or 5% dextrose injection stored at controlled room temperature and refrigerated conditions.
DOI
10.1310/hpj4806-484
Publication Information
Almagambetova, Elise; Hutchinson, David; Blais, Danielle M.; and Zhao, Fang (2013). "Stability of Diluted Adenosine Solutions in Polyolefin Infusion Bags." Hospital Pharmacy 48.6, 484-488.
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Comments
Elise Almagambetova, David Hutchinson, Danielle M. Blais, & Fang Zhao. Stability of Diluted Adenosine Solutions in Polyolefin Infusion Bags, Hospital Pharmacy (48.6) pp. 484-488. Copyright © 2013 SAGE Publications. Reprinted by permission of SAGE Publications.
The final published version of this article is available through the publisher: http://journals.sagepub.com/doi/full/10.1310/hpj4806-484