The Structure of Male Tail Sensory Cilia and CEM Cilia in the Absence of tbb-4 in the Model C. elegans

Authors

Katarina Weldy, St. John Fisher University
Dr. Daryl Hurd, St. John Fisher University

Document Type

Poster Presentation

Publication Date

4-25-2025

Keywords

fsc2025

Abstract

This presentation was originally presented at NCUR and another Scientific Conference. Abstract: Cilia are cellular cytoplasmic extensions made up of a microtubule based axoneme. The axoneme is composed of a ring of microtubules in either a 9+0 formation for stationary cilia or 9+2 for motile cilia. C. elegans has 60 ciliated sensory neurons and 16 genes that encode for tubulins. To understand the structure of cilia we are using tubulin mutations and tubulin fluorescent protein reporters. Our results show that one of the nine alpha-tubulin proteins, TBA-6, is exclusively expressed in ray neurons. TBA-6 is found in the dendrites at the end of the cilia. The beta-tubulin, TBB-4 has a sequence motif located in the ciliary beta-tubulins. Currently we are investigating the role of TBB-4 using the localization of TBA-6.

Comments

Student poster presented at the 2025 Fisher Showcase, St. John Fisher University, April 25, 2025.

Publication Information

Weldy, Katarina and Hurd, Dr. Daryl, "The Structure of Male Tail Sensory Cilia and CEM Cilia in the Absence of tbb-4 in the Model C. elegans" (2025). Fisher Showcase 2025. Paper 184.
https://fisherpub.sjf.edu/fsc2025/184

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