Teaching Analytical Method Transfer through Developing and Validating Then Transferring Dissolution Testing Methods for Pharmaceuticals
Document Type
Article
Publication Date
6-28-2017
Abstract
Analytical method transfer (AMT) and dissolution testing are important topics required in industry that should be taught in analytical chemistry courses. Undergraduate students in senior level analytical chemistry laboratory courses at Kennesaw State University (KSU) and St. John Fisher College (SJFC) participated in development, validation, and transfer of two dissolution testing methods for pharmaceuticals. These experiments were transferred between the two schools and underwent method equivalency testing by a different set of undergraduate students to validate the AMT. Student learning outcomes addressed at both SJFC and KSU include (1) significant learning gains across all 3 years of the study; (2) confidence in method development, writing standard operating procedures, and laboratory transfer of validated methods; (3) increased understanding of AMT and dissolution testing; (4) ability to operate dissolution testers, UV–vis, and flame atomic absorption spectrophotometers; and (5) improved knowledge and understanding of figures of merit and statistical analysis.
DOI
https://doi.org/10.1021/acs.jchemed.6b00878
Publication Information
Kimaru, Irene; Koether, Marina; Chichester, Kimberly D.; and Eaton, Lafayette (2017). "Teaching Analytical Method Transfer through Developing and Validating Then Transferring Dissolution Testing Methods for Pharmaceuticals." Journal of Chemical Education 97.8, 1066-1073.
Please note that the Publication Information provides general citation information and may not be appropriate for your discipline. To receive help in creating a citation based on your discipline, please visit http://libguides.sjfc.edu/citations.