TAC-1 depletion in C. Elegans using RNAi

Authors

Aleescia Cafferelli, St. John Fisher University

Document Type

Poster Presentation

Publication Date

4-25-2025

Keywords

fsc2025

Abstract

RNA (single stranded DNA) was fed to microscopic worms (nematodes) to inhibit a target gene. In this case, tac-1. Tac-1 is a microtubule associated-protein, and heavily involved in the cell cycle (cell division). When tac-1 is depleted in worms, the phenotype is observed and these observations can pave the way to understand TACC related cancer in humans. TACC related cancer has been seen in almost 90% of thyroid and breast cancers via over expression or under expression of TACC proteins.

Comments

Student poster presented at the 2025 Fisher Showcase, St. John Fisher University, April 25, 2025.

Publication Information

Cafferelli, Aleescia, "TAC-1 depletion in C. Elegans using RNAi" (2025). Fisher Showcase 2025. Paper 20.
https://fisherpub.sjf.edu/fsc2025/20

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