Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5
Cerebrovascular reactivity, HIV-1, Tat-transgenic mice, Hypercapnia, Phosphodiesterase-5
Cerebral blood flow (CBF) is known to be dysregulated in persons with human immunodeficiency virus 1 (HIV-1), for uncertain reasons. This is an important issue because impaired vasoreactivity has been associated with increased risk of ischemic stroke, elevated overall cardiovascular risk and cognitive impairment.
Silva, Jharon; Polesskaya, Oksana; Knight, Walter; Ting Zheng, Johnny; Granger, Megan; Lopez, Tenée; Ontiveros, Fernando; Feng, Changyong; Yan, Chen; Kasischke, Karl A.; and Dewhurst, Stephen (2012). "Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5." Journal of Neuroinflammation 9.253, 1-14.
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©2012 Silva et al. Journal of Neuroinflammation, Original publication is available at http://www.jneuroinflammation.com/content/9/1/253
This article is also available through PubMed Central® (PMC): https://www.ncbi.nlm.nih.gov/pubmed/23167821