Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform
The generation of a strong antibody response to target antigens is a major goal for vaccine development. Here we describe the display of the human immunodeficiency virus (HIV) envelope spike protein (Env) on a virus-like scaffold provided by the lambda phage capsid. Phage vectors, in general, have advantages over mammalian virus vectors due to their genetic tractability, inexpensive production, suitability for scale-up, as well as their physical stability, making them an attractive vaccine platform.
Mattiacio, Jonelle; Brewer, Matt; and Dewhurst, Stephen (2017). "Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform." Recombinant Virus Vaccines. Methods in Molecular Biology 1581, 245-253.
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Chapter published as: Mattiacio J.L., Brewer M., Dewhurst S. (2017) Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform. In: Ferran M., Skuse G. (eds) Recombinant Virus Vaccines. Methods in Molecular Biology, vol 1581. Humana Press, New York, NY
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