IL-1 Generated Subsequent to Radiation-induced Tissue Injury Contributes to the Pathogenesis of Radiodermatitis

Authors

Matthew Janko, University of Massachusetts Medical School
Fernando Ontiveros, St. John Fisher UniversityFollow
T. J. Fitzgerald, University of Massachusetts Medical School
A. Deng, University of Massachusetts Medical School
M. DeCicco, University of Massachusetts Medical School
Kenneth L. Rock, University of Massachusetts Medical School

Document Type

Conference Proceeding

Publication Date

10-2012

Abstract

Radiodermatitis is a condition in which the skin becomes inflamed and the epidermis can break down following radiation injury. In this study we developed a murine model of radiodermatitis where the skin is selectively injured by high-energy electron radiation. Using this model we investigated the interleukin-1 (IL-1) pathway in the development of radiodermatitis.

DOI

https://doi.org/10.1016/j.ijrobp.2012.07.1813

Comments

Presented at the American Society for Radiation Oncology 54th Annual Meeting in Boston, Massachusetts, October 2012.

Abstract included in the meeting's proceedings: a special issue of International Journal of Radiation Oncology*Biology*Physics. Volume 84, Issue 3, Supplement, 1 November 2012, Page S679. https://doi.org/10.1016/j.ijrobp.2012.07.1813

Publication Information

Janko, Matthew; Ontiveros, Fernando; Fitzgerald, T. J.; Deng, A.; DeCicco, M.; and Rock, Kenneth L. (2012). "IL-1 Generated Subsequent to Radiation-induced Tissue Injury Contributes to the Pathogenesis of Radiodermatitis." International Journal of Radiation Oncology Biology Physics 84.3, Supplement, S679-S679.

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